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Compensating for thalamocortical synaptic loss in Alzheimer's disease
Kamal Abuhassan,Damien Coyle,Liam Maguire
Frontiers in Computational Neuroscience , 2014, DOI: 10.3389/fncom.2014.00065
Abstract: The study presents a thalamocortical network model which oscillates within the alpha frequency band (8–13 Hz) as recorded in the wakeful relaxed state with closed eyes to study the neural causes of abnormal oscillatory activity in Alzheimer's disease (AD). Incorporated within the model are various types of cortical excitatory and inhibitory neurons, recurrently connected to thalamic and reticular thalamic regions with the ratios and distances derived from the mammalian thalamocortical system. The model is utilized to study the impacts of four types of connectivity loss on the model's spectral dynamics. The study focuses on investigating degeneration of corticocortical, thalamocortical, corticothalamic, and corticoreticular couplings, with an emphasis on the influence of each modeled case on the spectral output of the model. Synaptic compensation has been included in each model to examine the interplay between synaptic deletion and compensation mechanisms, and the oscillatory activity of the network. The results of power spectra and event related desynchronization/synchronization (ERD/S) analyses show that the dynamics of the thalamic and cortical oscillations are significantly influenced by corticocortical synaptic loss. Interestingly, the patterns of changes in thalamic spectral activity are correlated with those in the cortical model. Similarly, the thalamic oscillatory activity is diminished after partial corticothalamic denervation. The results suggest that thalamic atrophy is a secondary pathology to cortical shrinkage in Alzheimer's disease. In addition, this study finds that the inhibition from neurons in the thalamic reticular nucleus (RTN) to thalamic relay (TCR) neurons plays a key role in regulating thalamic oscillations; disinhibition disrupts thalamic oscillatory activity even though TCR neurons are more depolarized after being released from RTN inhibition. This study provides information that can be explored experimentally to further our understanding on the neurodegeneration associated with AD pathology.
Subperiosteal resection of mid-clavicle in Sprengel’s deformity correction
Freih Odeh Abuhassan
Strategies in Trauma and Limb Reconstruction , 2011, DOI: 10.1007/s11751-011-0115-2
Abstract: We report the results of fifteen cases of Sprengel’s deformity treated surgically by initial subperiosteal resection of the middle third of the clavicle in conjunction with surgical release of all attachments of the scapula to the spine, excision of any omovertebral bone and resection of prominent supraspinous process of scapula. The patients included ten female and three male patients (age range at the time of operation, 3.3–10 years; mean: 6.11 years). The deformity involved the left shoulder in eight patients, the right shoulder in three and two were bilateral. All patients were followed for an average of 5.9 years (range 4–11 years). Preoperatively, the arc of total abduction (glenohumeral and scapulothoracic) ranged from 80 to 140°, and the average was 110°. The shoulders were level, and the range of motion was dramatically improved with an average range of abduction of 166.5° (range 140–180°). The age of the patients and the presence of an omovertebral bone did not influence the results. All patients and their parents expressed satisfaction with the operative results. We feel that our procedure is a simple one, which helps to improve the degree of correction, avoid neurovascular complications and has the advantage of complete regeneration of the clavicle. The technique provides an easy, safe method of repositioning the scapula at its normal level.
Non-vascularized fibular graft reconstruction after resection of giant aneurysmal bone cyst (ABC)
Freih Odeh Abuhassan,Akram Shannak
Strategies in Trauma and Limb Reconstruction , 2010, DOI: 10.1007/s11751-010-0093-9
Abstract: The aim of this study was to present the results of non-vascularized fibular graft for reconstruction of bone defects after en block resection of giant aneurysmal bone cyst (ABC) of the extremities. Between 1998 and 2006, three patients, aged 6, 8 and 23 years, with giant aneurysmal bone cysts were treated. The cysts were located in the humerus, proximal femur and metatarsal. All patients were given en bloc resection of the cyst followed by non-vascularized fibular bone graft, with the graft length ranging from 6 to 18 cm. All patients needed supplementary fixation with a single Kirschner wire or plate and screws. At the final follow-up, bony union was achieved in each case, and there was no recurrence, limitation of range of motion or disability. In addition, complete regeneration of the fibula at the donor site was seen in the two children. We propose a criterion for giant ABC, when the transverse diameter of the cyst is up to three times or more of the transverse diameter of the nearby bone, it is then called a giant ABC. Non-vascularized fibular graft is an optimal and valuable method for the reconstruction of bone defects after resection of giant ABC in the extremities.
Dressing after Dressing: Sadra’s Interpretation of Change  [PDF]
Muhammad Kamal
Open Journal of Philosophy (OJPP) , 2013, DOI: 10.4236/ojpp.2013.31009
Abstract:

This paper deals with the doctrine of transubstantial change advocated by Mulla Sadra in which substances as well as accidents are thought to be in constant and gradual change. Against Aristotle’s doctrine of accidental change, Mulla Sadra argues that no stable ground can bring about change and since substance is renewable it cannot carry identity of a changing existent. Here we investigate whether identity is possible or not. If it is possible then what becomes a ground for establishing identity of changing substances.

Aliskiren Augments the Activities of Anti-Oxidant Enzymes in Liver Homogenates of DOCA Salt-Induced Hypertensive Rats  [PDF]
Sahar Kamal
Advances in Enzyme Research (AER) , 2014, DOI: 10.4236/aer.2014.22010
Abstract: Hypertension is a serious problem that is recently thought to be associated with damaging effects on target organs partially via oxidative stress. On the other hand, there is accumulating literature describing some sort of therapeutic interaction between antioxidant enzymes in vital organs and hypertension. Therefore, the aim of this study is to investigate the possible effect of a direct renin inhibitor, aliskiren, used in treatment of hypertension via renin-angiotensin-aldosterone system (RAAS), on selected anti-oxidant enzymes in hepatic homogenates in DOCA salt-induced hypertesnive albino rats. Thirty male wister albino rats were assigned randomly into 3 groups (n = 10/ group). Group 1 received no treatement and serves as control. Group 2 received 0.5% carboxymethylcellulose sodium ip as a solvent of aliskiren, as a direct renin inhibitor (DRI). Group 3 received aliskiren 100 mg/kg/day ip for 4 weeks through gastric tube. Systolic blood pressure (SBP) was measured every week and its mean was recorded at the end of the study. Superoxide dismutase (SOD) enzyme in RBCs lysates, activities of catalase (CAT) and glutathione peroxidase enzymes and thiobarbituric acid reactive substance (TBARS), as a marker of lipid peroxidation, in hepatic homogenates were measured at the end of the study. DRI produced a marked reduction in mean SBP of hypertensive rats. It also significantly (p < 0.05) increased the activities of measured anti-oxidant enzymes while it significantly (p < 0.05) reduced TBARS in liver homogenates. These results indicated that renin possesses an oxidative effect in the liver in hypertensive rats. Aliskiren, in addition to its powerful anti-hypertensive effect, it could induce a great anti-oxidant effect in liver homogenates of DOCA salt-hypertensive rats.
Individual Essences in Avicenna’s Metaphysics  [PDF]
Muhammad Kamal
Open Journal of Philosophy (OJPP) , 2014, DOI: 10.4236/ojpp.2014.41004
Abstract:

Central to Aristotle’s metaphysics is the question of individuality. The individuality of each substance is explained in relation to “matter” because the “form” is universal. Avicenna, as one of the Aristotelian Neoplatonist philosophers, is not content with this explanation and proposes to establish individuality on other grounds. In this paper, I argue that in his perspective it is not the “matter” which determines individuality but rather the principle of existence.

 

Metal-Like Gravity and Its Cosmological Applications  [PDF]
Kamal Barghout
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.518211
Abstract: Modification to Newton gravitational interaction is presented. It provides an understanding of a novel universal gravitational field of particle origin that defines alternative attributes to elementary constituents of matter particles and the gravitational interactions between them. It investigates gravitational relationship between two types of mass. The model assigns Coulombic gravitational interaction to DM particles and baryons by attributing self-antigravity to both normal matter and dark matter (DM). It defines the interaction as like particles repel while unlike particles attract. Metal-like force is proposed where same type mass (baryons) are gravitationally attracted to each other when a sea of DM particles are attracted to them and glue them together analogous to a metal bond. At close range, other dominant forces take place such as electromagnetic force. In light of this model, intergalactic self-repulsive DM particles are proposed to result in accelerating expansion of the universe. The model produces flat rotational curves for spiral galaxies and provides a physical explanation to MOND theory.
MLG vs. MOND  [PDF]
Kamal Barghout
Journal of Modern Physics (JMP) , 2015, DOI: 10.4236/jmp.2015.64053
Abstract: In a recently published paper Metal-Like Gravity (MLG) and Its Cosmological Applications [1], it was determined that a new modification of Newtonian gravity could explain many of the cosmological mysteries such as the nature of dark matter and dark energy. The theory provided a gravitational physical system and explained the flatness of the galactic rotational curves (RC). A RC fit that was identical to MOND’s RC fit for spiral galaxies was generated with α as a fitting parameter determined as equal to 1.345. In this paper I am elaborating more on the theory’s cosmological extrapolation of MOND’s critical acceleration a0. This is done by further assessing the gravitational interaction between the galactic baryonic mass and the halo-DM mass in the star-galaxy overlapping volume estimated in MLG framework interpreting a0 as only a factor induced from the reduction of the galactic luminous mass. It is asserted that MOND and MLG dynamic equations are equivalent with MOND’s form, only expressing the equation with an intermediate solution by equating the magnitudes of δ (a parameter that defines a scaled surface galactic DM-density perpendicular to the galactic radial direction in the galaxy-star halo overlapping volume) and G.
Avicenna’s Necessary Being  [PDF]
Muhammad Kamal
Open Journal of Philosophy (OJPP) , 2016, DOI: 10.4236/ojpp.2016.62018
Abstract: This article examines the distinctive characteristics of Avicenna’s doctrine of the Necessary Being, arguing that Avicenna developed his doctrine under the influence of Aristotle’s metaphysical thinking, but, unlike Aristotle he does not proceed from the distinction between form and matter. Instead, Avicenna has established his doctrine on essence-existence dichotomy. The article also investigates Avicenna’s view on God’s knowledge of particulars in light of his doctrine of the Necessary Being. The article begins by discussing Aristotle’s analysis of the meaning of the prime cause and its simplicity. It will then examine the simplicity of the Necessary Being in light of Aristotle’s metaphysics.
Ibn ‘Arabi and Spinoza on God and the World  [PDF]
Muhammad Kamal
Open Journal of Philosophy (OJPP) , 2017, DOI: 10.4236/ojpp.2017.74021
Abstract: This paper is a comparative analysis of Ibn ‘Arabi’s and Spinoza’s interpretation of God’s existence and its relation with the world. The focus will be on the ontology of these two thinkers from different intellectual traditions, elucidating their tripartite system in order to find out whether the reality of the world in its relationship to God is denied or affirmed. To vindicate the similarities between the ontological views of Ibn ‘Arabi and Spinoza this paper argues in light of God’s simplicity and causality that the existence of the world can be understood by denying and affirming its identity with God.
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